Lack of substantial advances in pre-clinical testing for hepatotoxicity has meant that drug-induced liver injury (DILI) remains an important issue during both the drug development and post-marketing phases. A number of drug-related, genetic and non-genetic host factors influence the risk of DILI in any individual. Demonstration of human leukocyte antigen genotype as a strong risk …
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Histopathological assessments play an important role in the diagnosis and management of patients with liver disease. For some conditions, liver biopsy is still routinely used to establish the cause of liver disease. In other circumstances, evaluation of morphological changes provides additional information that is useful for clinical management, for example when assessing disease severity in …
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Maribavir is a benzimidazole riboside with activity against cytomegalovirus (CMV). The safety and efficacy of maribavir for preemptive treatment of CMV infection in transplant recipients is not known. Design adds clarity. Using colour, typo graphy, hierarchy, contrast, and all the other tools at their disposal, designers can take an unordered jumble of… In a phase …
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Diabetes might be more deadly for women than men, at least when it comes to heart troubles, new research shows. Heart disease occurs an average of 15 years earlier in people with diabetes, and is their main cause of illness and death. In women, the connection between diabetes and heart disease is particularly strong. Worldwide, …
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Find information about world cancer statistics for the most common cancers (excluding non-melanoma skin cancer) in 2018, the latest year available. There were an estimated 18 million cancer cases around the world in 2018, of these 9.5 million cases were in men and 8.5 million in women. The most common cancers globally are listed in …
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The HPV vaccine gives parents a chance to prevent their children from developing some types of cancer, and two new studies reaffirm what past research has found — the vaccine is safe. The two studies included millions of doses of Gardasil 9 vaccine, the only vaccine currently used in the United States for the prevention …
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As cases of vaping-related lung injury climb, public health officials are scrambling for solutions to stem the epidemic. At the center of the debate: to ban vaping or not. Massachusetts became the first state to enact a law banning flavored tobacco and vaping products, including menthol cigarettes. The ban on flavored vaping products is effective …
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People with peanut allergy must be constantly vigilant to avoid a life-threatening allergic reaction. But researchers report that a new drug injection might offer at least temporary protection against the most severe reactions. Just one shot of an experimental antibody treatment allowed people with severe peanut allergy to eat about one peanut’s worth of peanut …
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Unlike some vaccines, there’s been so much demand for the new shingles vaccine Shingrix that it’s not always easy to find. It was approved in 2017, and the CDC recommends the vaccine for adults 50 and older to prevent this painful, blistering illness. It is being used in place of the previous vaccine, Zostavax. More …
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Here’s some worrisome news for folks who manage to survive a heart attack: New research suggests they might be far more vulnerable to developing cancer down the road. People who suffered a heart health scare — a heart attack, heart failure or a dangerously erratic heart rhythm — had a more than sevenfold increased risk …
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